7-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione → 7-(7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ylamino)-4,4-dimethylisoquinoline-1,3(2H,4H)-dione

HRID 2219979Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2219979
Cl[C:2]1[C:3]2[CH2:11][CH2:10][N:9]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][N:13]=3)[CH2:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:19][C:20]1[CH:29]=[C:28]2[C:23]([C:24]([CH3:33])([CH3:32])[C:25](=[O:31])[NH:26][C:27]2=[O:30])=[CH:22][CH:21]=1>C(#N)C>[Cl:18][C:17]1[C:12]([N:9]2[CH2:10][CH2:11][C:3]3[C:2]([NH:19][C:20]4[CH:29]=[C:28]5[C:23]([C:24]([CH3:33])([CH3:32])[C:25](=[O:31])[NH:26][C:27]5=[O:30])=[CH:22][CH:21]=4)=[N:7][CH:6]=[N:5][C:4]=3[CH2:8]2)=[N:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 2

HCID 135581517-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dioneHCID 590214784-Chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Produkt 1

HCID 120040697-(7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ylamino)-4,4-dimethylisoquinoline-1,3(2H,4H)-dioneAusbeute 50,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (7.5 mg), 7-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione (30 mg) (prepared according to the reference: Snow, R. J. et al, J. Med. Chem. 2002, 45, 3394), and acetonitrile (0.5 mL) was heated with microwave at 180° C. for 60 min. The solvent was removed and the residue was purified by chromatography to give an off-white solid (6 mg).

Aufarbeitung

  1. customprepared
  2. customThe solvent was removed
  3. customthe residue was purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e7b31749cff8400d9e08062a10550770
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07414131B2

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