HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | tert-Butyl (2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-yl)carbamate | HCID 59161518 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine | HCID 58216602 | — |
Reaction Steps
A mixture of tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate (1-5) (3.7 g, 9.63 mmol) in TFA (20 mL) was stirred at room temperature for 1 hour. The mixture was poured into a sat. NaHCO3 solution, extracted with CHCl3, dried (Na2SO4), filtered, and concentrated under reduced pressure to give 2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine (7-1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207169B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-bcf5fcd803f549af8344fb6eeee91c42 |
| Source note | uspto-grants-2012_06 |