HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Amino-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Product | 4-Amino-L-proline | HCID 21120376 | — |
Reaction Steps
To the resin is added the corresponding acylating agent (usually a carboxyxlic acid (R64′COOH, 3 equiv.), HBTU (22.3 mg, 4 equiv.), HOBt (8 mg, 4 equiv.) and DIEA (125 μL, 6 equiv.) in DMF (2 mL) for 1.5-2 hrs at room temperature. The resin is filtered, washed with 2×DMF, 3×CH2Cl2, 2×DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417024B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-4c21d7cff73345e09a024fe5725dd111 |
| Source note | uspto-grants-2008_08 |