HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2220054Generated: November 3, 2026
Triphenylphosphine → 4-Bromo-2-(bromomethyl)-1-chlorobenzene
https://huagongshe.com/reaction/2220054
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | (5-Bromo-2-chlorophenyl)methanol | HCID 5074766 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-2-(bromomethyl)-1-chlorobenzene | HCID 11558280 | — |
Reaction Steps
4.0 g N-bromosuccinimide are slowly added to a solution of 5.0 g 1-bromo-4-chloro-3-hydroxymethyl-benzene and 5.9 g triphenylphosphine in 50 ml of tetrahydrofuran cooled to 5° C. After 1 h stirring at ambient temperature the precipitate is filtered off and the solvent is eliminated in vacuo. The residue is purified on silica gel (cyclohexane/ethyl acetate 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07417032B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-b256cc5300b64f9b81605bbe3b0ef741 |
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| Source note | uspto-grants-2008_08 |
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