Triethyl phosphite → HCID 58596993, compound

HRID 2220055Notes

Reaction equation

HRID 2220055 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH:9]=1)[CH2:7]Br.[CH2:11]([O:13][P:14]([O:18]CC)[O:15][CH2:16][CH3:17])[CH3:12]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH:9]=1)[CH2:7][P:14](=[O:18])([O:15][CH2:16][CH3:17])[O:13][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 31215Triethyl phosphite2×HCID 115582804-Bromo-2-(bromomethyl)-1-chlorobenzene

Product 1

HCID 58596993HCID 58596993, compound

Conditions

Temperature
130 °C

Procedure

A mixture of 9.88 g 5-bromo-2-chloro-benzylbromide in 6.10 ml triethylphosphite is stirred for 3 h at 130° C. Then a further 1.50 ml triethylphosphite are added, and the mixture is stirred for a further 3 h at 160° C. After cooling to ambient temperature the mixture is purified on silica gel (dichloromethane/methanol 1:0->9:1).

Workup

  1. stirringthe mixture is stirred for a further 3 h at 160° C
  2. temperatureAfter cooling to ambient temperature the mixture
  3. customis purified on silica gel (dichloromethane/methanol 1:0->9:1)

Sources & evidence

ORD record
ord-e849d4a88ad24fd5976a0eeb1516689a
Source dataset
uspto-grants-2008_08
Patent number
US07417032B2

Reaction notes

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