反应详情

To a solution of 1-benzo[1,3]dioxol-5-yl-2-(6-methyl-pyridin-2-yl)-ethanone of Step B (2 g, 7.83 mmol) in acetic acid (15 mL) was slowly added a solution of bromine (0.40 mL, 1 equiv) in acetic acid (5 mL). The resulting reaction mixture was stirred at ambient temperature for 1 h, concentrated in vacuo, diluted with diethyl ether (20 mL) and methylene chloride (10 mL). The resulting suspension was stirred at ambient temperature for 16 hours, and then filtered to yield the title compounds as a light beige solid (3.0 g, 92%).

1. customThe resulting reaction mixture
2. concentrationconcentrated in vacuo
3. additiondiluted with diethyl ether (20 mL) and methylene chloride (10 mL)
4. stirringThe resulting suspension was stirred at ambient temperature for 16 hours
5. filtrationfiltered