Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 3-(1-Propyl-4-piperidinyl)phenol | HCID 12988959 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11522227 | HCID 11522227 | — |
Reaction Steps
A solution of 3-(1-propyl-piperidin-4-yl)-phenol (340 mg) and triethylamine (187 mg) in 20 ml of CH2Cl2 was cooled to 0° C. Then methanesulfonyl chloride (194 mg) dissolved in 10 ml of CH2Cl2 was added dropwise. The reaction mixture was allowed to reach room temperature and then stirred for 2.5 h at 25° C. The reaction was finally quenched with water. The organic layer was separated and washed with 10% HCl and then 10% Na2CO3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07417043B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-3770ea98b00c459fbad1cf62171245b0 |
|---|
| Source note | uspto-grants-2008_08 |
|---|
