HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1,2,3,6-Tetrahydro-4-(3-(methylthio)phenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester | HCID 12988964 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,2,3,6-Tetrahydro-4-(3-(methylthio)phenyl)pyridine | HCID 12988965 | — |
Reaction Steps
4-Hydroxy-4-(3-methylsulfanyl-phenyl)-piperidin-1-carboxylic acid tert-butyl ester (3.97 g) was dissolved in CH2Cl2 (500 ml) and trifluoroacetic acid (80 ml) was added in one portion. The mixture was refluxed for one hour and then washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 2.07 g. MS m/z (relative intensity, 70 eV) 205 (M+, 73), 158 (44), 129 (95), 128 (80), 82 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417043B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-f3519a99f49b4cc4813845475c58d895 |
| Source note | uspto-grants-2008_08 |