HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Thionyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5,6-Dichloronicotinic acid | HCID 247987 | — |
| Product | Thionyl Chloride | HCID 24386 | — |
| Product | 5,6-Dichloropyridine-3-carbonitrile | HCID 12878464 | — |
Reaction Steps
2,3-Dichloro 5-cyano pyridine 4 was prepared from 5,6-Dichloronicotinic acid (ALDRICH). The acid was converted to the acid chloride by treatment with excess SOCl2 and refluxed for 1.5 hours. The intermediate acid chloride was reacted with ammonia (aqueous) to get the primary amide which on dehydration with excess SOCl2 at reflux condition afforded 2, 3-Dichloro 5-cyano pyridine 4. [Ref. George et al J. Org. Chem, 1979, 44, 2697.]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417045B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-65feb5be5904477f952ae700c52e2641 |
| Source note | uspto-grants-2008_08 |