反应详情

温度

-78 °C

n-Butyllithium (1.6M, 11 mL, 17.38 mmol) was added to a solution of oxazole (1.0 g, 14.48 mmol) in anhydrous ether (20 mL) stirred at −78° C. under nitrogen. After 5 min, triethylstannyl bromide (2.07 g, 7.24 mmol) was added, then the reaction mixture was allowed to warm to room temperature, and stirred for another 1 h. The mixture was quenched, and washed with 1N sodium hydroxide, dried through MgSO4, and then the solvent was evaporated to give the sub-title compound as a brown oily residue (1.0 g), which was used without further purification in the next step.

1. temperatureto warm to room temperature
2. stirringstirred for another 1 h
3. customThe mixture was quenched
4. washwashed with 1N sodium hydroxide
5. dry with materialdried through MgSO4
6. customthe solvent was evaporated