3-(Imidazol-5-yl)-5-methoxy-6-methylindene → HCID 67529444, compound

HRID 2220179Notes

Reaction equation

HRID 2220179 reaction equation
[NH:1]1[C:5]([C:6]2[C:14]3[C:9](=[CH:10][C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH2:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1>[Pd].C(O)C.O.[Pt]=O>[NH:1]1[C:5]([CH:6]2[C:14]3[C:9](=[CH:10][C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH2:8][CH2:7]2)=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 1

HCID 675307833-(Imidazol-5-yl)-5-methoxy-6-methylindene

Product 1

HCID 67529444HCID 67529444, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 86587499Platinum oxide monohydrateCatalystHCID 702EthanolSolvent

Procedure

This compound was prepared in a manner analogous to that of Step E of Example 1, by the hydrogenation of 0.5 gram (0.0022 mole) of 3-(imidazol-5-yl)-5-methoxy-6-methylindene (viii) in the presence of 0.1 gram (catalyst) of 10% palladium on carbon and 0.1 gram (catalyst) of platinum oxide hydrate in 40 mL of ethanol. The yield of subject compound was 0.42 gram, mp 68-70° C. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step E of Example 1

Sources & evidence

ORD record
ord-8ea05362b53b4eb1b3ba986c2b194a4b
Source dataset
uspto-grants-2008_08
Patent number
US07417057B2

Reaction notes

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