HCID 67530309, compound → HCID 67531321, compound

HRID 2220190Notes

Reaction equation

HRID 2220190 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:18])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8][CH:7]=1>[Pd].C(O)C.[Pt]=O>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:18])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8][CH2:7]1

Participants

5

Reactant 1

HCID 67530309HCID 67530309, compound

Product 1

HCID 67531321HCID 67531321, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

This compound was prepared in a manner analogous to that of Step C of Example 7, by the hydrogenation of 0.7 gram (0.003 mole) of 4-imidazol-2-yl-6-methoxy-7-methyl-1,2-dihydronaphthalene (xiii) using a Parr hydrogenator, in the presence of 0.1 gram (catalyst) of platinum oxide and 0.1 gram (catalyst) of 10% palladium on carbon in 50 mL of ethanol. The yield of the subject compound was 0.34 gram, mp 168-169° C. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step C of Example 7

Sources & evidence

ORD record
ord-dacd3c0a71e34144896daf36a8b66bda
Source dataset
uspto-grants-2008_08
Patent number
US07417057B2

Reaction notes

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