Potassium Carbonate → HCID 68894696, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of Example 222 (20 mg, 0.05 mmol) in CH2Cl2 (1 mL) was added one drop of DMF. The solution was cooled to 0° C., oxalyl chloride (3 μl, 0.055 mmol) was added and the reaction mixture was stirred for 30 minutes. The reaction mixture was concentrated to a yellow solid, taken up in sulfolane and treated with K2CO3 (14 mg, 0.1 mmol) and 1,2,3-triazine (3 μl, 0.05 mmol). The mixture was heated at 140° C. for 5 hours, then water was added. The resulting mixture was filtered, and the solid was purified by preparative reversed-phase HPLC to give the title compound (3.3 mg, 15%). HPLC Rt=2.36 (b) min. m/z=427 (M+H+).

Provenance & Evidence