m-Chloroperbenzoic acid → HCID 68968184, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound Example 287A (32 mg, 0.095 mmol) in CH2Cl2 (5 mL) at 0° C. was added mCPBA (13 mg, 0.05 mmol). The solution was stirred for 1 hour at 0° C. and for 1 hour at room temperature. The reaction was quenched by adding NaHCO3 solution. The aqueous layer was extracted with EtOAc (3×2 mL). The combined EtOAc extracts were washed with brine and dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (SiO2, 2:1 hexane/EtOAc) to give the title compound (24 mg, 77 %). HPLC Rt=3.7 min. m/z=354(M+H+).

Provenance & Evidence