関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | 4-Bromo-2-methylbenzonitrile | HCID 144267 | — |
| 反応物 | N-Bromosuccinamide | HCID 9834204 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 4-Bromo-2-(bromomethyl)benzonitrile | HCID 25140608 | 102.7% |
反応手順
To a stirred mixture of 4-Bromo-2-methyl-benzonitrile (5.00 g, 25.5 mmol) in CCl4 (40 mL) under argon was added N-bromosuccinamide (5.00 g, 28.1 mmol) and a catalytic amount of benzoyl peroxide. This mixture was heated at 85° C. for 2 days and cooled to room temperature. The precipitate was filtered off and the cake was rinsed with CCl4 (2×10 mL). The filtrate was concentrated in vacuo to give 7.2 g crude 4-Bromo-2-bromomethyl-benzonitrile (quantitative yield) which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07417040B2 |
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| 出典データセット | uspto-grants-2008_08 |
|---|
| ORD ID | ord-f5b83e452c964f2b90ffde53367cf9bf |
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| 出典メモ | uspto-grants-2008_08 |
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