HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminoquinoline → 5-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminoquinoline | HCID 11911 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-(2,3-Dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal | HCID 44184989 | — |
| Reactant | HCID 68851814 | HCID 68851814 | — |
| Product | 5-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]quinoline | HCID 11575970 | — |
Reaction Steps
Analogously to Example 1, 4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal is converted with 5-aminoquinoline into 5-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylidenamino]quinoline, which is reduced with sodium borohydride to the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417056B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-6157d2380b7646d48fafc8bf2f1e4af8 |
| Source note | uspto-grants-2008_08 |