HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 5-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]-2-methylisoquinol-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Amino-2-methyl-1(2H)-isoquinolinone | HCID 12220344 | — |
| Reactant | 4-(2,3-Dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal | HCID 44184989 | — |
| Product | 5-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]-2-methylisoquinol-1(2H)-one | HCID 11719905 | — |
Reaction Steps
Analogously to Example 1, 4-(2,3-dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal is converted with 5-amino-2-methylisoquinol-1(2H)-one into the corresponding imine. After reaction with sodium borohydride, the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417056B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-bbddf909183f4a5db701bd4390ba31d8 |
| Source note | uspto-grants-2008_08 |