HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → HCID 11989686, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | HCID 11989685 | HCID 11989685 | — |
| Product | HCID 11989686 | HCID 11989686 | 61% |
Reaction Steps
According to Step 6, after reaction of 3-Bromo-5-(4-tert-butylbenzene-sulfonylamino)-1-benzothiophene-2-carboxylic acid ethyl ester (469 mg, 1.0 mmol) from Example 1c) with phenylboronic acid (176 mg, 1.44 mmol) followed by chromatographic purification (silica gel, hexane/ethyl acetate (0-100% ethyl acetate) and ethyl acetate/methanol (0-15%)), the desired compound is obtained at 61% yield (300 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417066B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-e9a5377913b04965aeaa90c3c0e050f7 |
| Source note | uspto-grants-2008_08 |