1-(Benzyl-methyl-amino)-heptan-3-ol → (4-Cyclohexyl-3-hydroxy-butyl)-methyl-carbamic acid tert-butyl ester

HRID 2220350Notes

Reaction equation

HRID 2220350 reaction equation
C(N(C)CCC(O)CCCC)C1C=CC=CC=1.[C:18]([O:22][C:23](=[O:37])[N:24]([CH2:26][CH2:27][C:28](=[O:36])[CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1)[CH3:25])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:37])[N:24]([CH2:26][CH2:27][CH:28]([OH:36])[CH2:29][CH:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1)[CH3:25])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 179819331-(Benzyl-methyl-amino)-heptan-3-olHCID 59769551(4-Cyclohexyl-3-oxo-butyl)-methyl-carbamic acid tert-butyl ester

Product 1

HCID 59769577(4-Cyclohexyl-3-hydroxy-butyl)-methyl-carbamic acid tert-butyl ester

Procedure

Using a method similar to that for 1-(Benzyl-methyl-amino)-heptan-3-ol, (4-cyclohexyl-3-oxo-butyl)-methyl-carbamic acid tert-butyl ester affords the title compound: 1H NMR (CDCl3) δ 3.90-3.80 (m, 1H), 3.62-3.52 (m, 1H), 2.88-2.96 (m, 1H), 2.83 (s, 3H), 1.80-1.60 (m, 6H), 1.56-1.32 (m, 3H), 1.47 (s, 9H), 1.31-1.08 (m, 4H), 0.98-0.77 (m, 2H).

Sources & evidence

ORD record
ord-a1fdd2b652a44bc3abec8b5722f9874d
Source dataset
uspto-grants-2008_08
Patent number
US07417064B2

Reaction notes

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