1,4-Dioxane hydrochloride → HCID 42639132, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl][2-[3′-(isopropoxy)-4′-[[(methylsulfonyl)amino]-carbonyl]-4-biphenylyl]ethyl]carbamate (65 mg) in 1,4-dioxane (2 ml) was added hydrochloric acid 1,4-dioxane solution (4N, 4 ml) at room temperature and the mixture was stirred at the same temperature for 2.5 hours. The mixture was evaporated under reduced pressure to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-isopropoxy-N-(methylsulfonyl)-4-biphenylcarboxamide hydrochloride (38 mg).

Provenance & Evidence