Hydrogen chloride-ethyl acetate → HCID 69103530, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl][2-[3′-isopropoxy-4′-[[(pentylsulfonyl)amino]-carbonyl]-4-biphenylyl]ethyl]carbamate (170 mg) in ethyl acetate (2 ml) was added hydrochloric acid ethyl acetate solution (4N, 4 ml) at room temperature and the mixture was stirred at the same temperature overnight. The mixture was filtered to collect the precipitate and the precipitate was washed with ethyl acetate. The precipitate was dried under reduced pressure to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-isopropoxy-N-(pentylsulfonyl)-4-biphenylcarboxamide hydrochloride (106 mg).

Provenance & Evidence