Ethanol → HCID 69103443, compound

Participants

Reaction Steps

To a solution of methyl 3-(isopropylthio)-4′-[2-methyl-2-[(trifluoroacetyl)amino]propyl]-4-biphenylcarboxylate (810 mg) in ethanol was added sodium hydroxide aqueous solution (1M, 9 ml) at room temperature and stirred under reflux for 4 hours. The resultant mixture was evaporated. The residue was dissolved with hydrogen chloride solution in ethanol (5.5M, 12 ml) and stirred at room temperature overnight. The resultant mixture was evaporated and dried to give ethyl 4′-(2-amino-2-methylpropyl)-3-(isopropylthio)-4-biphenylcarboxylate (384 mg).

Provenance & Evidence