Ammonium formate → HCID 69103685, compound

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Reaction Steps

The mixture of methyl 4′-[2-[[(benzyloxy)carbonyl]-amino]-2-methylpropyl]-3-isobutyl-4-biphenylcarboxylate (570 mg), ammonium formate (351 mg) and palladium on carbon powder (400 mg) in methanol (10 ml) and water (1.0 ml) was refluxed for 3 hours. The catalyst was filtered off, and the filtrate was diluted with chloroform-methanol (19:1). The organic layer was washed with saturated aqueous sodium bicarbonate solution and brine, dried over magnesium sulfate, and evaporated to give methyl 4′-(2-amino-2-methylpropyl)-3-isobutyl-4-biphenylcarboxylate (372 mg).

Provenance & Evidence