Ethanol hydrochloride → HCID 69103672, compound

HRID 2220417Notes

Reaction equation

HRID 2220417 reaction equation
[ClH:1].[OH:2][C@H:3]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:4][NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[C:16]([S:23][CH:24]([CH3:26])[CH3:25])[CH:15]=2)=[CH:10][CH:9]=1.[CH2:33](O)[CH3:34].Cl>>[ClH:1].[OH:2][C@H:3]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:4][NH:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([O:22][CH2:33][CH3:34])=[O:21])=[C:16]([S:23][CH:24]([CH3:26])[CH3:25])[CH:15]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 24823135HCID 24823135, compound

Product 1

HCID 69103672HCID 69103672, compound

Procedure

The suspension of 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride in hydrogen chloride ethanol solution (5.5M, 1 ml) was stirred under reflux for 1.5 hours. The mixture solution was evaporated under reduced pressure and the resultant solid was washed with isopropyl ether to give ethyl 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-4-biphenylcarboxylate hydrochloride (37 mg).

Workup

  1. temperatureunder reflux for 1.5 hours
  2. customThe mixture solution was evaporated under reduced pressure
  3. washthe resultant solid was washed with isopropyl ether

Sources & evidence

ORD record
ord-da7d7ad0cc7a47589151bdd9efb64f6b
Source dataset
uspto-grants-2008_08
Patent number
US07417060B2

Reaction notes

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