Acetone → Toluene acetone

HRID 2220501Notes

Reaction equation

HRID 2220501 reaction equation
[CH3:1][C:2]([CH3:4])=[O:3].[C:5]1([CH3:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>>[C:5]1([CH3:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:1][C:2]([CH3:4])=[O:3]

Participants

3

Reactant 2

HCID 180AcetoneHCID 1140Toluene2×

Product 1

HCID 20247278Toluene acetoneYield 80%

Conditions

Temperature
7.5 °C

Procedure

60 ml of acetone, 30 ml of toluene and the solution in toluene of the product of Example 2 were introduced into a 500 ml flask equipped with a mechanical stirrer, a thermometer and a dropping funnel. The solution was cooled to 5-10° C. and gaseous HCl was bubbled. through the solution. The mixture was then kept at 5-10° C. for 1 h, then the precipitate was filtered out and washed with 1/1 toluene/acetone (yield 80%; 99% A)

Workup

  1. customequipped with a mechanical stirrer
  2. customgaseous HCl was bubbled
  3. filtrationthe precipitate was filtered out

Sources & evidence

ORD record
ord-a728f69a90574e3cb04508cc001ed5da
Source dataset
uspto-grants-2008_08
Patent number
US07417149B2

Reaction notes

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