Imidazole → HCID 58346545, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for example 277, utilizing 2-(6-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-4,5-dihydro-3H-pyrimido[5′,4′:4,5]thieno[2,3-e]indazol-3-yl)ethyl methanesulfonate (1.53 g, 3.0 mmol), imidazole (17 mg, 0.25 mmol), and diisopropylethylamine (0.06 mL, 0.34 mmol). The desired product was collected as a white solid (37 mg, 39%). 1H-NMR (CD2Cl2-d2) δ 8.26 (s, 1H), 8.04 (s, 1H), 7.98 (s, 1H), 7.65 (s, 1H), 7.50 (d, 1H), 7.40 (d, 1H), 7.21-7.38 (m, 2H), 6.90-7.00 (m, 3H), 6.82 (dd, 1H), 6.72 (s, 1H), 5.60 (s, 2H), 4.42 (t, 2H), 4.35 (t, 2H), 3.17 (t, 2H), 2.40 (t, 2H); LCMS RT=2.58 min; [M+H]+=562.4

Provenance & Evidence