Potassium tert-butoxide → HCID 178480890, compound

Participants

Reaction Steps

To a yellow suspension of 3-[2-(4-methyl-piperazin-1-yl)-ethyl]-6-[2-(4-nitro-phenyl)-ethoxy]-4,5-dihydro-3H-10-thia-2,3,7,9-tetraaza-cyclopenta[a]fluorene (2.7 g, 5.2 mmol) in THF (125 ml) was added potassium tert-butoxide (0.92 g, 7.79 mmol) in one portion. The reaction mixture became a solution and then turned into a dark black solution. After stirring for 30 min, analytical HPLC showed no more starting material and two new major peaks. Solvents were evaporated and the dark residue was suspended in EtOAc. To above suspension was added 5 ml of 4M HCl and it turned into a light yellow suspension. The crude HCl salt of the desired product was collected by filtration, washed with EtOAc, and air-dried to afford the crude product (2.2 g, 104%). RT=0.41 min; [M+H]+=371.2.

Provenance & Evidence