Acetic Acid → HCID 23134154, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (0.233 g), acetic acid (0.2 mL), water (2 mL) and 1,4-dioxane (2 mL) was stirred at 75° C. for 2 days. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/5-1/3) to afford 4-ethoxycarbonyl-2,6-dimethylphenylboronic acid (0.047 g).

Provenance & Evidence