Water → HCID 23134229, compound

Participants

Reaction Steps

Acetyl chloride (0.226 mL) was added to a mixture of 1-[4′-(2-hydroxyethoxy)-2′,6′-dimethylbiphenyl-4-yl]ethan-1-one (0.75 g) and triethylamine (0.556 mL) in methylene chloride (2 mL), and the mixture was stirred at room temperature for 20 minutes. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/3-1/2) to afford 1-[4′-(2-acetoxyethoxy)-2′,6′-dimethylbiphenyl-4-yl]ethan-1-one (0.672 g).

Provenance & Evidence