Hydrochloric Acid → HCID 69202144, compound

Participants

Reaction Steps

Ethyl 4′-[(R)-2-(tert-butoxycarbonylamino)propyloxy]biphenyl-4-carboxylate was dissolved in ethanol (30 mL), and a 48% solution of hydrogen chloride in ethanol (5 mL) was added dropwise to the solution at room temperature with stirring. After being stirred at that temperature for 5 hrs, the reaction mixture was concentrated in vacuo. The residue was purified by aminopropyl silica gel flash column chromatography (eluent: methylene chloride/ethyl acetate=1/1 and methylene chloride/methanol=10/1) to afford the title compound (0.484 g).

Provenance & Evidence