Tetrabutylammonium Fluoride → HCID 69201859, compound

Participants

Reaction Steps

Ethyl 4′-{(R)-2-[(R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-triethylsilanyloxyethylamino]propyloxy}biphenyl-4-carboxylate was dissolved in tetrahydrofuran (5.70 mL), and a 1 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (0.63 mL) was added dropwise to the solution at room temperature with stirring. After being stirred at that temperature for 13 hrs, the reaction mixture was concentrated in vacuo. The residue was purified by silica gel flash column chromatography (eluent: methylene chloride/ethyl acetate=1/1 and methylene chloride/methanol=10/1) to afford the title compound (0.284 g).

Provenance & Evidence