Water → HCID 69203626, compound

Participants

Reaction Conditions

Reaction Steps

N-[5-{(R)-1-hydroxy-2-[2-(4′-methoxybiphenyl-4-yloxy)ethylamino]ethyl}-2-(2-trimethylsilylethoxymethoxy)-phenyl]-N-(2-trimethylsilylethoxymethyl)methanesulfonamide was dissolved in acetonitrile (0.25 mL). Water (0.05 mL) and a 1 mol/L solution of lithium tetrafluoroborate in acetonitrile (0.26 mL) were added to the solution, and the mixture was stirred at 80° C. for 3 hrs. The reaction mixture was purified by reverse phase column chromatography (Shiseido Capcell Pak MG ODS, 5 μm, 120 Å, 20×50 mm, Flow rate 30 mL/minute, linear gradient 0.1% aqueous formic acid/acetonitrile=90/10-10/90 over 5 minutes). The fraction was concentrated in vacuo to afford the title compound (0.009 g).

Provenance & Evidence