Dimethylformamide → HCID 11663953, compound

Participants

Reaction Steps

Part B. 3-bromo-4-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-N-pyridin-2-ylmethyl-benzamide: A mixture of the compound of Part A (0.18 g, 0.47 mmol), 2-aminomethylpyridine (0.058 mL, 0.56 mmol), NMM (0.4 mL, 3.8 mmol) and BOP reagent (0.26 g, 0.59 mmol) in DMF (1.5 mL) was stirred overnight at rt. Reaction mixture was diluted with water and extracted with EtOAc. Organic layer was washed with brine, dried over anh. Na2SO4, filtered and evaporated. Chromatography on silica gel provided the amide product (0.2 g, 91%). LC/MS m/z 473.2, 475.2 (M+H)+.

Provenance & Evidence