Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 11570291, compound

Participants

Reaction Steps

Part A. 2′-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-4-methoxy-5′-[(oxazol-2-ylmethyl)-carbamoyl]-biphenyl-2-carboxylic acid: A mixture of the compound of Example 15, Part F (75 mg, 0.138 mmol), oxazol-2-yl-methylamine hydrochloride (28 mg, 0.208 mmol) NMM (0.012 mL, 1.10 mmol) and BOP reagent (76 mg, 0.172 mmol) in DMF (1 mL) was stirred at rt over 3 days. Reaction was worked up and product isolated as described for Example 15, Part G to provide the amide (78.3 mg, 91%). LC/MS m/z 625.3 (M+H)+.

Provenance & Evidence