3-Pyridinemethanamine → HCID 11606358, compound

Participants

Reaction Steps

Part E. 2′-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-4-methyl-5′-[(pyridin-3-ylmethyl)-carbamoyl]-biphenyl-2-carboxylic acid benzyl ester: The compound of Part D was coupled with 3-aminomethylpyrdine using the procedure described for Example 15, Part G to provide the amide in 88% yield. 1H NMR (500 MHz, CDCl3) δ ppm 1.38 (t, J=7.42 Hz, 3H) 2.41 (s, 3H) 3.79 (s, 2H) 4.04 (q, J=7.15 Hz, 2H) 4.60 (m, 2H) 4.94 (m, 2H) 6.29 (t, J=5.50 Hz, 1H) 6.67 (s, 1H) 6.97 (d, J=7.70 Hz, 1H) 7.03 (m, 2H) 7.16 (d, J=8.25 Hz, 1H) 7.24 (m, 7H) 7.44 (s, 1H) 7.56 (s, 1H) 7.67 (t, J=8.52 Hz, 2H) 7.82 (s, 1H) 8.53 (s, 1H) 8.57 (s, 1H). LC/MS m/z 619.4 (M+H)+.

Provenance & Evidence