2-(Aminomethyl)-5-methylpyrazine → HCID 11555891, compound

Participants

Reaction Steps

Part A. 2′-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-4-methyl-5′-[(5-methylpyrazin-2-ylmethyl)-carbamoyl]-biphenyl-2-carboxylic acid benzyl ester: The compound of Example 37, Part D was coupled with 2-aminomethyl-5-methylpyrazine using the procedure described for Example 15, Part G to provide the amide in 84% yield. 1H NMR (500 MHz, CDCl3) δ ppm 1.37 (t, J=7.42 Hz, 4H) 2.41 (s, 3H) 2.55 (s, 3H) 3.78 (s, 2H) 4.03 (q, J=7.51 Hz, 2H) 4.71 (dd, J=11.00, 4.95 Hz, 2H) 4.95 (m, 2H) 6.66 (s, 1H) 7.01 (m, 4H) 7.17 (dd, J=14.30, 8.25 Hz, 2H) 7.24 (m, 4H) 7.51 (s, 1H) 7.55 (s, 1H) 7.67 (d, J=8.25 Hz, 1H) 7.83 (s, 1H) 8.36 (s, 1H) 8.52 (s, 1H).

Provenance & Evidence