HCID 11606358, compound → HCID 11713718, compound

Participants

Reaction Steps

Part A. 2′-(6-cyano-1-ethyl-1H-indol-3-ylmethyl)-4-methyl-5′-[(pyrimidin-2-ylmethyl)-carbamoyl]-biphenyl-2-carboxylic acid: The amide was prepared in 55% yield from the acid of Example 37, Part D following the procedure of Example 37, Part E using 2-aminomethylpyrimidine oxalate in place of 3-aminomethylpyridine. 1H NMR (500 MHz, CDCl3) δ ppm 1.38 (t, J=7.42 Hz, 3H) 2.41 (s, 3H) 3.79 (s, 2H) 4.03 (q, J=7.15 Hz, 2H) 4.86 (m, 2H) 4.96 (m, 2H) 6.67 (s, 1H) 7.03 (m, 3H) 7.17 (dd, J=15.40, 8.25 Hz, 2H) 7.24 (m, 5H) 7.41 (t, J=12 Hz, 1H) 7.56 (s, 1H) 7.60 (s, 1H) 7.74 (d, J=9.90 Hz, 1H) 7.84 (s, 1H) 8.71 (d, J=0.40 Hz, 2H). LC/MS m/z 620.4 (M+H)+.

Provenance & Evidence