HCID 57747318, compound → HCID 44124457, compound

Participants

Reaction Steps

tert-Butyl 4-(2,6-dimethyl-4-(pyridin-4-yl)phenoxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl4-cyanophenylcarbamate was treated with TFA (10 mL) at 25° C. for 2 h. TFA was evaporated, the obtained residue dissolved in EtOAc, and extracted with saturated aqueous NaHCO3 (×2). The organic layer was collected, concentrated, and the product purified by chromatography (SiO2, 1:4 hexanes/EtOAc) to give the title compound as a solid (277 mg, 100%). 1H NMR (400 MHz, CDCl3-CD3OD (5:1), 25° C.) δ 8.67 (bs, 2H), 7.63 (m, 3H), 7.50 (s, 2H), 7.43 (d, J=8.8 Hz, 2H), 7.32 (d, J=3.0 Hz, 1H), 7.26 (d, J=8.7 Hz, 2H), 6.43 (d, J=2.9 Hz, 1H), 4.16 (s, 3H), 2.27 (s, 6H).

Provenance & Evidence