Trifluoroacetic acid → HCID 58622270, compound

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Reaction Steps

Experimental condition analogous to Example 4, from 2-(S)-(biphenyl-3-ylaminomethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 1 g (2.84 mmol), 3,4-dimethoxy-benzoyl chloride 0.6 g (2.98 mmol), and triethylamine 0.43 g (4.26 mmol), and 25 mL of dichloromethane. After purification on silica using gradient of chloroform-ethylacetate (20-1 to 10-1) gave 1 g of white semi solid compound: LC-MSD, m/z for: C31H36N2O5 [M+H]: 517.6. LC retention time on HPLC, C18 column gradient 20-95% acetonitrile with 0.1% TFA in 7 minutes: 5.093

Provenance & Evidence