HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 28165431, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | BOC-D-alanine | HCID 637606 | — |
| Product | HCID 28165431 | HCID 28165431 | — |
| Product | HCID 28165731 | HCID 28165731 | — |
Reaction Steps
(R)-tert-butoxycarbonylalanine cyclopropylamide (15) was prepared as described in General Procedure 1 using (R)-tert-butoxycarbonylalanine and cyclopropyl amine. Intermediate 16 was prepared as illustrated in General Procedure 7. A solution of 1.0 eq. of 15 in THF was prepared. While stirring, 1.5 eq. of 60% NaH in mineral oil was added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417152B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-a40eabe16ff647178ed8ce8452cd69b6 |
| Source note | uspto-grants-2008_08 |