HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 4-(Pyridin-4-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-(4-(Methoxymethoxy)phenyl)pyridine | HCID 57747377 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(Pyridin-4-yl)phenol | HCID 135410177 | 78.9% |
Reaction Steps
A solution of 4-(4-(methoxymethoxy)phenyl)pyridine (240 mg, 1.11 mmol) in aqueous HCl (1N, 2.8 mL) was stirred at rt overnight. The reaction was neutralized with saturated NaHCO3 and the precipitate was collected by filtration to yield the desired compound as a white solid (150 mg). NMR (MeOH-d4): 8.49 (d, 2H), 7.65 (m, 4H), 6.92 (d, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207178B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-eb656ed4bbfa423cbac8c109b11c7339 |
| Source note | uspto-grants-2012_06 |