HCID 59773586, compound → HCID 59773423, compound

HRID 2220752Notes

Reaction equation

HRID 2220752 reaction equation
[N:1]([CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:11][C:10]=2[CH:20]=1)=[N+]=[N-]>C(O)C.[Pd]>[C:14]1([C:12]2[NH:11][C:10]3[CH:20]=[C:6]([CH2:5][CH2:4][NH2:1])[CH:7]=[CH:8][C:9]=3[N:13]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 1

HCID 59773586HCID 59773586, compound

Product 1

HCID 59773423HCID 59773423, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Azide 192 was dissolved in ethanol and 10% Pd/C (50 mg) was added. H2 was applied at 40 psi with vigorous shaking. After 2 h, TLC analysis indicated complete consumption of starting material. The heterogeneous reaction mixture was filtered through Celite, and the filtrated was concentrated under reduced pressure to give 193.

Workup

  1. customconsumption of starting material
  2. filtrationThe heterogeneous reaction mixture was filtered through Celite
  3. concentrationthe filtrated was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4a04a544b5b0480388b28e10e3b59b0a
Source dataset
uspto-grants-2008_08
Patent number
US07417152B2

Reaction notes

Loading…