HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → HCID 178522628, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Selectfluor | HCID 2724933 | — |
| Reactant | 4-Methyl-5-(2-chloro-benzoylamino)-1-(pyridine-2-yl)-pyrazole-3-carboxylic acid(2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)amide | HCID 59812227 | — |
| Reactant | HCID 178524563 | HCID 178524563 | — |
| Product | HCID 178522628 | HCID 178522628 | — |
Reaction Steps
The pyrazole acid, prepared using compound 23 and SELECTFLUOR™ (Aldrich, 43,947-9) using a procedure similar to that described in Katoch-Rouse, R. et al., J. Med. Chem. 2003, 46, 642, was coupled to 2-(1-pyrimidin-2-yl-piperidin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417152B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-f8131e8d666b49bd98eb8c53019e3096 |
| Source note | uspto-grants-2008_08 |