反应详情

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in deionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixture was adjusted to 10 to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

1. customto precipitate the Bupivacaine base
2. filtrationThe precipitated product was filtered
3. washfurther washed with DI water at least three times
4. customThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours