tert-Butoxycarbonyl-D-leucine → HCID 59709833, compound

HRID 2220813Notes

Reaction equation

HRID 2220813 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:14]([OH:16])=O)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:18][C@H:19]([C:23]([O:25][CH3:26])=[O:24])[CH2:20][CH2:21][CH3:22]>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:14]([NH:18][C@H:19]([C:23]([O:25][CH3:26])=[O:24])[CH2:20][CH2:21][CH3:22])=[O:16])[CH2:10][CH:11]([CH3:12])[CH3:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 637604tert-Butoxycarbonyl-D-leucineHCID 14118488methyl (2S)-2-aminopentanoate hydrochloride

Product 1

HCID 59709833HCID 59709833, compound

Procedure

N-(tert-Butoxycarbonyl)-D-leucine (1000 mg, 4.32 mmol) and methyl L-norvalinate hydrochloride (1090 mg, 6.49 mmol) are reacted by general procedure 6. The crude product is purified by workup method 1. The product is obtained in quantitative yield.

Workup

  1. customThe crude product is purified by workup method 1
  2. customThe product is obtained in quantitative yield

Sources & evidence

ORD record
ord-9c36f46bb6dc4fe88f248e6d2b99d251
Source dataset
uspto-grants-2008_05
Patent number
US07368424B2

Reaction notes

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