HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butoxycarbonyl-D-leucine → Benzyl n-(tert-butoxycarbonyl)-d-leucyl-3-tert-butyl-l-alaninate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butoxycarbonyl-D-leucine | HCID 637604 | — |
| Reactant | L-Leucine, 4-methyl-, phenylmethyl ester, hydrochloride (9CI) | HCID 68803323 | — |
| Product | Benzyl n-(tert-butoxycarbonyl)-d-leucyl-3-tert-butyl-l-alaninate | HCID 59709729 | — |
Reaction Steps
N-(tert-Butoxycarbonyl)-D-leucine (230 mg, 1.0 mmol) and benzyl-3-tert-butyl-L-alaninate hydrochloride (300 mg, 1.10 mmol) (John X. He, Wayne L. Cody, Annette M. Doherty, J. Org. Chem., 1995, 60, 8262-8266) are reacted by general procedure 6. The crude product is purified (workup method 2) by preparative HPLC (method 16), resulting in 362 mg (80% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368424B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-0bbb223aea8442d887cc74085e9313cd |
| Source note | uspto-grants-2008_05 |