HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Methoxy-5-morpholinoaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-(4-Methoxy-3-nitrophenyl)morpholine | HCID 17747010 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methoxy-5-morpholinoaniline | HCID 11367778 | 88% |
Reaction Steps
4-(4-Methoxy-3-nitro-phenyl)-morpholine (6 g) is hydrogenated in dichloromethane (100 ml) and methanol (600 ml) using palladium on carbon (10%, 600 mg) for 12 hours. The catalyst is removed by filtration and the solution evaporated in vacuo. Purification by flash chromatography (silica, eluent ethyl acetate/n-hexane 1:1) affords the product as off-white solid (4.6 g, 88%). MS: m/e=209 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07368446B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-61da2c74e958402c9e98b6b29a7a03ce |
| Source note | uspto-grants-2008_05 |