HCID 86599711, compound → HCID 11399093, compound

HRID 2220857Notes

Reaction equation

[Cl:1]C1C=CC(C(O)=O)=C(OCC2C3C(OC(C)(C)O3)C(N3C=NC4C3=NC=NC=4NC(NC3C=CC=CC=3)=O)O2)N=1.Cl[C:43]1[N:51]=[C:50]([O:52][CH2:53][CH:54]2[CH:61]3[CH:57]([O:58][C:59]([CH3:63])([CH3:62])[O:60]3)[CH:56]([N:64]3[CH:72]=[N:71][C:70]4[C:65]3=[N:66][CH:67]=[N:68][C:69]=4[NH:73][C:74]([NH:76][C:77]3[CH:82]=[CH:81][CH:80]=[CH:79][CH:78]=3)=[O:75])[O:55]2)[CH:49]=[CH:48][C:44]=1[C:45]([OH:47])=[O:46]>>[Cl:1][C:49]1[C:50]([O:52][CH2:53][CH:54]2[CH:61]3[CH:57]([O:58][C:59]([CH3:63])([CH3:62])[O:60]3)[CH:56]([N:64]3[CH:72]=[N:71][C:70]4[C:65]3=[N:66][CH:67]=[N:68][C:69]=4[NH:73][C:74]([NH:76][C:77]3[CH:78]=[CH:79][CH:80]=[CH:81][CH:82]=3)=[O:75])[O:55]2)=[N:51][CH:43]=[C:44]([CH:48]=1)[C:45]([OH:47])=[O:46]

Participants

Reactant 2

HCID 86599711HCID 86599711, compound

HCID 86599712HCID 86599712, compound

Product 1

HCID 11399093HCID 11399093, compound

Procedure

6-Chloro-2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid (isomer A) & 2-Chloro-6-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid (isomer B):

Sources & evidence

ORD record: ord-04a214a541544f0cbcdd7e49a0d2526c
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07368438B2

Reaction notes

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