2-Thiopheneglyoxylic acid → 2(1H)-Quinoxalinone

HRID 2220878Notes

Reaction equation

HRID 2220878 reaction equation
CO[C:3]1[CH:4]=[C:5]([NH2:12])[C:6]([NH2:11])=[CH:7][C:8]=1OC.S1C=CC=C1[C:18](=O)[C:19](O)=[O:20]>>[NH:12]1[C:5]2[C:6](=[CH:7][CH:8]=[CH:3][CH:4]=2)[N:11]=[CH:18][C:19]1=[O:20]

Participants

3

Reactant 2

HCID 776942-Thiopheneglyoxylic acidHCID 1529391,2-Diamino-4,5-dimethoxybenzene

Product 1

HCID 145262(1H)-Quinoxalinone

Procedure

The quinoxalin-2-one of the present example is prepared with 4,5-Dimethoxy-benzene-1,2-diamine and (thiophen-2-yl) oxo-acetic acid via the method described in Example 12 to afford 6,7-Methoxy-3-thiophen-2-yl-1H-quinoxalin-2-one.

Sources & evidence

ORD record
ord-0d3ee7b5e9a8474fa1a20b80451c39a3
Source dataset
uspto-grants-2008_05
Patent number
US07368452B2

Reaction notes

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