HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178480490, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 24989579 | HCID 24989579 | — |
| Product | HCID 178480490 | HCID 178480490 | 60% |
Reaction Steps
To a solution of 1-methyl-1,6-dihydro-1,6,7-triaza-as-indacene-3-carboxylic acid B2 (0.232 mmol) dry DMF (2 mL), HOBT.NH3 (0.464 mmol), TBTU (0.464 mmol) and DIEA (0.08 mL) were added. The mixture was stirred at rt for 24 h. The reaction mixture was concentrated and the residue was chromatographed on silica gel (eluant: DCM/MeOH 20:1). The title compound was obtained in 60% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207180B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-59d01f2928414330a075af79844b6265 |
| Source note | uspto-grants-2012_06 |